ea0044s2.3 | Grappling with the future of anti-inflammatory steroids | SFEBES2016
Gibbs Julie
, Loudon Andrew
, Ray David
The circadian clock is a key regulator of immune responses. Both circulating and resident immune cells possess intrinsic timers, which act to impart time-of-day variation in their function. It is now becoming evident that the circadian clock is also critically involved in regulating the function of endogenous anti-inflammatory glucocorticoid hormones. Consequently, we see variation in an animals inflammatory responses dependent on the time the stimulus was delivered. Thi...